Millions of people worldwide are currently concerned by age-related diseases. This number is likely to increase exponentially as the population continues to age: according to the World Health Organisation “By 2050, the world’s population aged 60 years or older is expected to total 2 billion”. Age-related diseases have a tremendous impact on individuals, families and societies. International organisations recognise healthy ageing for all citizens as a main priority. With the aim to meet this challenge, we decided to identify and investigate innovative therapeutic strategies to provide long-term solutions for patients suffering from age-related neurodegenerative diseases for which only few to no treatments exist.